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Dr Catherine Flynn

Consultant Haematologist, National Bone Marrow Transplant Centre

Over 1,400 family donor and unrelated donor transplants have been performed in Ireland for life-threatening blood cancers including leukaemia, lymphoma and myeloma.


The first bone marrow transplant was performed in St James’s Hospital Dublin in 1984 under the supervision of Professor Shaun McCann. These patients who have had a donor transplant include young adults and, more recently, patients up to 68 years old. Patients are referred to St James’s for transplant by blood and cancer specialists all over Ireland.

Susceptibility to blood cancers can increase with age but, with improved longevity in Ireland, (as highlighted in the recent TILDA project directed by Professor Kenny, TCD) older, fitter patients are seeking out this high risk – but potentially life-changing – procedure to cure their disease.

What is a transplant?

Allogeneic bone marrow transplantation involves transferring the stem cells from a healthy donor to a patient following chemotherapy or radiation. The cells can be harvested from a family member, usually a sibling or an unrelated matching donor.

With decreasing family sizes and increased ethnic diversity in modern Ireland, more unrelated donors are required than ever before. Close links between our National Adult Bone Marrow transplant centre and the Irish unrelated donor registry (IBMTR) are critical in finding the best matched unrelated donors for Irish patients.

What are the symptoms of blood cancer?

When a patient presents with leukaemia or lymphoma, they will often have bleeding (nose bleeds, excessive bruising or internal bleeding), infection (repeated infections that fail to respond to antibiotics) or swollen lymph glands (in the neck, under the arms or hidden in the chest or abdomen).

Several diseases can have similar symptoms to these including viral illnesses such as glandular fever, HIV or other cancers and it is important to get medical advice to assist in making the correct diagnosis. Typically, an examination and blood tests will lead to referral to a specialist centre where additional scans and tests including a bone examination will make a definite diagnosis.

Technology is supporting patients after transplant

Technology is advancing to make diagnoses quicker and assess responses to initial treatment. The most successful transplants happen when the disease is well controlled at the beginning of the procedure.

The advantage of a donor cell transplant is that, when successful, the patient has a new bone marrow and a new immune system. Many patients return to the workplace and family life and some pursue new adventures with their second chance. All transplant survivors in St James’s hospital are invited to attend an annual medical review to optimise their long-term health. Looking after our increasing number of transplant survivors is a growing challenge.

Help us celebrate

To celebrate 35 years of bone marrow transplantation in Ireland and World Marrow Donor day 2019, The Second All-Ireland Bone Marrow Transplant conference is being held on Friday 20th of September 2019 for healthcare professionals involved in the field and a patient and family day will take place on the morning of Saturday 21st September 2019. Both these events will be held in Durkan Lecture Theatre, Trinity Centre, St James’s Hospital, Dublin 8. All are welcome.

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