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Early relapse in follicular lymphoma patients not fully understood

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Dr Amjad Hayat

Consultant Haematologist, Galway University Hospital

Life expectancy for patients with follicular lymphoma is good. But there are significant gaps in knowledge, support and provision that need addressing.


Patients with advanced forms of follicular lymphoma can expect to live 20 years or more. However, due to the biological and clinical heterogeneity.

Better understanding of the complexity of the disease comes from research. This will ensure that patients receive the best possible (and ideally tailored) treatment according to risk factors.

Early identification

Despite excellent outcomes, life-expectancy of patients who experience a progression of the disease within 24 months is considerably lower. “Only 50% overall survival as compared to 90% in patients without early relapse,” confirms Dr Amjad Hayat.

Early identification is essential. This helps us understand why their outcomes are so much worse. Following this, investigate the best treatment options.

Assessing long-term outlook to tailor therapy

Currently, we are assessing the long-term outlook for each patient and then tailoring therapy to the individual. This is a vital area of ongoing research in cancer. The Follicular Lymphoma International Prognostic Index (FLIPI), which takes into account five key factors that affect prognosis, has gone some way to providing this but is not used to tailor treatment or predict early relapse. Further refinements of the prognostic score also fail in accurately predicting early progression of disease and prognostic scores remain research tools.

More recently, the use of PET scans at the end of treatment has been reported as an independent prognostic marker. Positive PET scans at the end of immunochemotherapy have been shown to be useful in identifying individuals at high risk of an early relapse. A refinement of PET, that refers to the total volume of active disease pre-treatment ‘total metabolic tumour volume’ (TMTV) could be a useful predicting tool. But there are still many unknowns.

Unknowns when using PET scans

A refinement of PET, that refers to the total volume of active disease pre-treatment ‘total metabolic tumour volume’ (TMTV) could be a useful predicting tool. But there are still many unknowns.

Uncertainty around diagnosis can be very distressing for patients

Even for those patients who go on to live relatively normal lives, the weight of uncertainty that comes with a diagnosis of follicular lymphoma can be hugely detrimental to their quality of life.

By the time a patient seeks help a high percentage will already have advanced stage lymphoma.

As a slow-developing cancer, that remains incurable, despite significant improvements in standard treatment, the first course of action could be ‘watchful waiting,’ which often adds to a patient’s anxiety.

This is an issue that Hayat believes needs to be addressed. “Most patients are waiting for something dreadful to happen and we need to do more to provide them psychological support.”

Effective therapies

When it comes to treatment, there are plenty of effective therapies out there. First line treatments can include radiotherapy, if the condition is localised, along with a combination of chemo-immunotherapy. Patients commonly receive maintenance drugs in the years following.

New options, such as new monoclonal antibodies, immunomodulatory agents, drugs targeting selective cellular pathways and CART-T cell therapy, are on the horizon too. But Hayat believes many patients in Ireland could be missing out on academic clinical trials, allowing early access to these newer developments due to a lack of funding. As part of the Lymphoma Forum of Ireland, Hayat is advocating for greater access, particularly for patients who experience an early relapse.

Progress moving forwards

There is no denying the progress that has been made. Helping patients living with follicular lymphoma through improved research.

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